Advancing Appropriate Models for Translational Studies in Human Brains
Time: 9:00 am
day: Pre-Conf Workshop Track B AM
Details:
- Analyzing the successful validation of a gene therapy in a rodent animal model
- Deep diving into successfully transitioning from rodent models to NHP studies to prove safety and appropriate biodistribution in large brain organisms
- Using human cells to scale dosage before conducting NHP studies
- Discussing humanized mouse models when modelling CNS gene therapies
- Understanding the differences in AAV tropism between rodent models and large animal models
