Successfully Scaling CNS Gene Therapy Dosage when Translating into NHPs
Time: 1:30 pm
day: Day Two Whole
Details:
- Outlining the limitations of allometric scaling for CNS directed gene therapies when translating from rodents to NHPs
- Discussing strategies to maintain efficacy of transduction during translational studies
- Employing a layered approach and harnessing PBPK modelling to create a comprehensive model for dose prediction in NHPs to maintain safety and efficacy
